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In our study, it was There was no neonate with the temperature shown that continuous spinal labor anesthesia above 38 and administered with antibiotics. with sufentanil induced a rise in maternal 338 Int J Clin Exp Med 2013;six(five):334-Sufentanil can induce maternal febrile response in labor analgesiaTable three. Comparisons of maternal cytokine concentrations amongst the two groupsParameter IL-6 (pgml) IL-8 (pgml) TNF- (pgml)Sufentanil group (Imply D) Baseline five min right after Delivery five.77.50 16.30.01 16.33.70 28.02.57 47.097.44 47.446.Control group (Mean D) Baseline 5 min soon after Delivery six.02.21 16.51.77 16.72.25 29.04.19 50.500.61 48.368.Important distinction to baseline within groups, P0.05. No difference is found involving the two groups.tion of temperature within the spinal cord can have an effect on the activity of thermoregulatory neurons in the preoptic region (POA) . One more issue is the dosage of sufentanil that we utilised six ug in bolus, two mlh in maintenance which was smaller sized than other relevant studies . Other studies showed that systemic administration of opioids mostly generated biphasic effects on body temperature in mouse: Figure four. Comparisons in the neonatal imply temperature at different time building hyperthermia points amongst the two groups. All values represent the signifies D. The temwith low dosage and hypoperature will not be located to be unique in between the two groups in any time point. thermia with high dosage [17, 27]. Our research that intrathecal administration of sufentanil with intrapartum temperature, disaccording using the low dosage induced intrapartum fever additional other researchers’ benefits. We interpreted the proved the results in former studies. difference of our final results because the women received a various opium drug (sufentanil) using a differSeveral studies showed that the elevated ent approach. maternal temperature was not considerably The mechanism of this fever continues to be unclear and associated with inflammation . On the conthe hypothesis that central thermoregulatory trary, others reported that this fever was attribresponse is impaired by regional anesthesia is uted to infection and epidural techniques could possibly the crucial point . Unique opium drugs boost the danger of infection. Even so, these act on distinctive opium receptors, which are results have been based on histological findings localized inside the POA on the anterior hypoalone with out the proof of bacterial culture thalamus, play distinct roles in thermoregula. IL-6, IL-8 and TNF- are inflammatory faction [17, 22]. The efficacy of sufentanil which can be tors which can represent the degree of inflammaabout 1,000 instances of morphine  includes a tion . In our results, the inflammatory facselective bond and high-affinity to website . tors of IL-6, IL-8 and TNF- level in maternal The receptor was reported to possess an effect serum had been all with no significant difference on building hyperthermia [12, 22]. The methbetween the two groups, although, the degree of od that we administered sufentanil in the space IL-6 and IL-8 improved in all parturients irreof subarachnoid but not epidural can also be a facspectively of groups throughout the delivery. All of tor. It has wealthy receptors of temperature sensathese meant that the CSLAS related fever was tion and difficult afferent pathways in subnot related together with the inflammatory aspects arachnoid . The afferent pathways start a.